Parallel measurement alarm processor

ABSTRACT

An alarm processor has a signal input responsive to a physiological parameter and a plurality of parameter processors responsive to the signal input so as to provide a plurality of different measurements of the parameter. In addition, the alarm processor has an alarm condition applicable to at least one of the measurements so as to define a limit for the parameter. Further, the alarm processor has an alarm indicator operating on the measurements and the alarm condition so as to provide an alarm output that changes state to indicate that the parameter may have exceeded the limit.

CROSS REFERENCE TO RELATED APPLICATION

The present application claims priority benefit under 35 U.S.C. §119(e) from U.S. Provisional Application No. 60/351,510, filed Jan. 24, 2002, entitled “Parallel Measurement Alarm Processor,” which is incorporated herein by reference.

BACKGROUND OF THE INVENTION

Physiological measurement instruments employed in healthcare environments often feature visual and audible alarm mechanisms that alert a caregiver when a patient's vital signs are outside of predetermined limits. One example is a pulse oximeter, which measures the oxygen saturation level of arterial blood, an indicator of oxygen supply. A typical pulse oximeter displays a numerical readout of the patient's oxygen saturation, a numerical readout of pulse rate, and a plethysmograph, which is indicative of a patient's pulse. In addition, a pulse oximeter provides an alarm that warns of a potential desaturation event.

FIG. 1 illustrates a prior art pulse oximeter portion 100 having a signal input 101 and generating an oxygen saturation measurement output 103 and an alarm output 105. The pulse oximeter portion 100 has an oxygen saturation (SpO₂) processor 110 and an associated threshold detector 120. The SpO₂ processor 110 derives an oxygen saturation measurement from the signal input 101. The signal input 101 is typically an amplified, filtered, digitized and demodulated sensor signal. A sensor emits both red and infrared (IR) wavelength light, which is transmitted through a patient's tissue, detected and input to the pulse oximeter. The pulse oximeter calculates a normalized ratio (AC/DC) of the detected red and infrared intensities, and an arterial oxygen saturation value is empirically determined based on a ratio of these normalized ratios, as is well-known in the art. The oxygen saturation measurement output 103 is typically a digital signal that is then communicated to a display.

FIG. 2 illustrates the operation of a conventional threshold detector 120 (FIG. 1) utilizing a graph 200 of oxygen saturation 201 versus time 202. The graph 200 displays a particular oxygen saturation measurement 210 corresponding to the measurement output 103 (FIG. 1) and a predetermined alarm threshold 206. During an alarm time period 270 when the measured oxygen saturation 210 is below the threshold 206, an alarm output 105 (FIG. 1) is generated, which triggers a caregiver alert. Adjusting the threshold 206 to a lower value of oxygen saturation 201 reduces the probability of an alarm, i.e. reduces the probability of a false alarm and increases the probability of a missed event. Likewise, adjusting the threshold 206 to a higher value of oxygen saturation 201 increases the probability of an alarm, i.e. increases the probability of a false alarm and decreases the probability of a missed event.

SUMMARY OF THE INVENTION

One performance measure for a physiological measurement instrument is the probability of a false alarm compared with the probability of a missed event. Missed events, such as an oxygen desaturation when measuring oxygen saturation, may detrimentally effect patient health. False alarms waste caregiver resources and may also result in a true alarm being ignored. It is desirable, therefore, to provide an alarm mechanism to reduce the probability of false alarms without significantly increasing the probability of missed events, and, similarly, to reduce the probability of missed events without significantly increasing the probability of false alarms.

An alarm processor has a signal input responsive to a physiological parameter and a plurality of parameter processors responsive to the signal input so as to provide a plurality of measurements of the parameter having differing characteristics. In addition, the alarm processor has an alarm condition applicable to at least one of the measurements so as to define a limit for the parameter. Further, the alarm processor has an alarm indicator operating on the measurements and the alarm condition so as to provide an alarm output that changes state to indicate that the parameter may have exceeded the limit.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a block diagram of a prior art pulse oximeter portion;

FIG. 2 is a graph of oxygen saturation versus time illustrating a conventional threshold detector alarm;

FIG. 3 is a block diagram of an alarm processor utilizing parallel measurements of a physiological parameter;

FIG. 4 is a block diagram of a pulse oximeter processor utilizing dual oxygen saturation measurements;

FIG. 5 is a block diagram of a predictive alarm indicator utilizing a threshold detector with a slow oxygen saturation measurement input and a slope detector with a fast oxygen saturation measurement input;

FIGS. 6A-B are graphs of oxygen saturation versus time illustrating operation of the alarm indicator according to FIG. 5;

FIG. 7 is a block diagram of a pattern recognition alarm indicator utilizing a threshold detector with a slow oxygen saturation measurement input and a pattern extractor with a fast oxygen saturation measurement input; and

FIG. 8 is a graph of oxygen saturation versus time illustrating the pattern recognition alarm indicator according to FIG. 7.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT

FIG. 3 illustrates a parallel measurement alarm processor 300. The alarm processor 300 has a sensor signal input 301 responsive to a physiological parameter and provides one or more alarm outputs 303 to indicate that the physiological parameter may have exceeded particular limits. The alarm processor 300 also has multiple parameter processors 310, which do not necessarily have the same or similar internal configurations. The multiple parameter processors 310 input the sensor signal 301 and provide parallel measurements 312 of the physiological parameter, each measurement having differing characteristics, such as response time or bandwidth to name a few. The alarm processor 300 further has an alarm indicator 320 that inputs the parallel parameter measurements 312 and generates the alarm outputs 303 based upon alarm conditions 305. The alarm outputs 303 change state to indicate that the parameter may have exceed one or more limits and to trigger an alarm accordingly. The alarm conditions 305 define particular limits with respect to one or more of the measurements 312. The alarm conditions 305 may be predefined, such as by user input, or determined by a separate process, such as a measurement of sensor signal quality or data confidence as described in U.S. patent application Ser. No. 09/858,114, now U.S. Pat. No. 6,684,090, entitled “Pulse Oximetry Data Confidence Indicator,” assigned to Masimo Corporation, Irvine, Calif. and incorporated by reference herein. The alarm processor 300 may also have a display driver 330 that processes one or more of the parameter measurements 312 and provides one or more display outputs 307.

FIG. 4 illustrates a pulse oximeter embodiment 400 of the alarm processor 300 (FIG. 3) described above. A pulse oximeter sensor (not shown) provides a signal input 301 responsive to arterial oxygen saturation, as described with respect to FIG. 1, above. The alarm processor 400 has dual oxygen saturation processors 310. An integrator oxygen saturation (SpO₂) processor 410 outputs a slow SpO₂ measurement 412, i.e. a measurement having a slow response time to changes in the SpO₂ parameter. A predictor SpO₂ processor 420 outputs a fast SpO₂ measurement 422, i.e. a measurement having a fast response time that tracks changes in the SpO₂ parameter. The slow SpO₂ measurement 412 is input to a display driver 330, which provides an oxygen saturation display output 307. For example, the display output 307 may be input to a digital display that provides a numerical readout of oxygen saturation to a caregiver. Both the slow SpO₂ measurement 412 and the fast SpO₂ measurement 422 are input to an alarm indicator 320 that generates at least one alarm output 303 based upon alarm conditions 305, as described in further detail with respect to FIGS. 5-8, below.

The integrator SpO₂ processor 410, advantageously, provides a smoothed measurement of oxygen saturation suitable for threshold detection. The predictor SpO₂ processor 420, advantageously, provides a curve-fitting or a predictive measurement of oxygen saturation that detects trends in oxygen saturation, as described in further detail with respect to FIG. 5 and FIGS. 6A-B, below. Further, the predictor SpO₂ processor 420 advantageously tracks oxygen saturation details that may signal a critical physiological event, as described in further detail with respect to FIGS. 7-8, below. The integrator SpO₂ processor 410 and predictor SpO₂ processor 420 may be a pulse oximeter as described in U.S. patent application Ser. No. 09/586,845, now U.S. Pat. No. 6,430,525, entitled “Variable Mode Averager,” assigned to Masimo Corporation, Irvine, Calif. and incorporated by reference herein.

FIG. 5 illustrates a trend embodiment of an alarm indicator 320, which has a threshold detector 510, a slope detector 520 and alarm detector 530. The threshold detector 510 has a slow SpO₂ measurement 412 and a threshold alarm condition 305 as inputs and a logic output BELOW 512. The slope detector 520 has a fast SpO₂ measurement 422 input and a logic output POSITIVE/ 522. The alarm detector 530 has BELOW 512 and POSITIVE/ 522 logic inputs and generates an alarm output 303. The threshold detector 510 is a comparator that asserts BELOW 512 while the slow SpO₂ measurement 412 is less in value than the value of the threshold 305. The slope detector 520 is a differentiator and comparator that asserts POSITIVE/ 522 while the slope of the fast SpO₂ measurement 422 is non-positive, i.e. while the derivative of the fast SpO₂ measurement 422 is zero or less than zero. The alarm detector 530 performs a logical AND function, asserting the alarm output 303 and indicating an alarm when BELOW 512 and POSITIVE/ 522 are both asserted. In this manner, an alarm output 303 only changes state when the slow SpO₂ measurement 412 is below a threshold 305 and the fast SpO₂ measurement 422 has not begun to increase in value. Advantageously, the trend recognition alarm indicator 320 reduces false alarms by suppressing a threshold-based alarm on the slow SpO₂ measurement 412 when the fast SpO₂ measurement 422 determines that a patient's oxygen saturation is in recovery, as described in further detail with respect to FIGS. 6A-B, below.

FIGS. 6A-B illustrate operation of the trend recognition alarm indicator 320 (FIG. 5). In FIG. 6A, a graph 600 has an SpO₂ axis 601 and a time axis 602. Shown along the SpO₂ axis 601 is a constant SpO₂ value 606 corresponding to a threshold 305 (FIG. 5). The graph 600 shows a first plot of SPO² versus time 610 corresponding to a fast SpO₂ measurement 422 (FIG. 5). The graph 600 also shows a second plot of SpO₂ versus time 620 corresponding to a slow SpO₂ measurement 412 (FIG. 5). A suppressed alarm interval 640 along the time axis 602 corresponds to an alarm that would be indicated by the threshold detector 510 (FIG. 5) but is suppressed as occurring during a positive slope portion 630 of a fast SpO₂ measurement 610. The alarm detector 530 (FIG. 5) would not assert an alarm output 303 (FIG. 5) during this interval.

In FIG. 6B, a graph 650 shows a first plot of SpO₂ versus time 660 corresponding to a fast SpO₂ measurement 422 (FIG. 5). The graph 650 also shows a second plot of SpO₂ versus time 670 corresponding to a slow SpO₂ measurement 412 (FIG. 5). An alarm interval 690 along the time axis 602 corresponds to an alarm period triggered by the alarm output 303 (FIG. 5). This alarm interval 640 occurs while a slow SpO₂ measurement 670 is below the threshold 606 and before a positive slope portion 680 of a fast SpO₂ measurement 660.

FIG. 7 illustrates a pattern recognition embodiment of an alarm indicator 320, having a threshold detector 710, a pattern extractor 720, a pattern memory 730 and a pattern comparator 740. Further, the alarm indicator 320 has slow SpO₂ 412 and fast SpO₂ 422 measurement inputs in addition to threshold 701 and reference pattern 732 alarm condition inputs 305. The threshold detector 710 has a slow SpO₂ measurement 412 and a SpO₂ threshold 701 as inputs and a first alarm output 712. The threshold detector 710 changes the state of the first alarm output 712 when the value of the slow SpO₂ measurement 412 crosses the SpO₂ threshold 701. For example, the first alarm output 712 changes state to trigger an alarm when the slow SpO₂ measurement 412 becomes less than the SpO₂ threshold 701.

As shown in FIG. 7, the pattern extractor 720 has a fast SpO₂ measurement 422 and a pattern threshold 734 as inputs and an extracted pattern output 722. The pattern extractor 720 identifies features of the fast SpO₂ measurement 422 that may be used for pattern matching. Features may be, for example, the number of times the fast SpO₂ measurement 422 crosses the pattern threshold 734 within a certain time period, or the duration of each time period that the fast SpO₂ measurement 422 is less than the pattern threshold 734, to name a few. The pattern memory 730 has a pattern selection input 705 and a reference pattern output 732. The pattern memory 730 stores values for particular features that are identified by the pattern extractor 720. The reference pattern output 732 transfers these stored values to the pattern comparator 740. The pattern memory 730 may be nonvolatile and one or more patterns may be stored at the time of manufacture or downloaded subsequently via a data input (not shown). One of multiple patterns may be determined via the pattern selection input 705, by a user or by a separate process, for example. The pattern threshold 734 may be generated in response to the pattern selection input 705 or in conjunction with a selected reference pattern 732.

Also shown in FIG. 7, the pattern comparator 740 has the extracted pattern 722 and the reference pattern 732 as inputs and generates a second alarm output 742. That is, the pattern comparator 740 matches extracted measurement features provided by the pattern extractor 720 with selected features retrieved from pattern memory 730, changing the state of the second alarm output 742 accordingly. For example, the second alarm output 742 changes state to trigger an alarm when features of the fast SpO₂ measurement 422 match the reference pattern output 732. Advantageously, the pattern recognition alarm indicator 320 reduces missed events by supplementing the threshold-based first alarm output 712 responsive to the slow SpO₂ measurement 412 with a pattern-based second alarm output 742 responsive to detail in the fast SpO₂ measurement 422. In this manner, if a patient's oxygen saturation is, for example, irregular or intermittent, the second alarm output 742 may trigger a caregiver alert when the first alarm output 712 does not, as described in further detail with respect to FIG. 8, below.

FIG. 8 illustrates operation of a pattern recognition alarm indicator 320 (FIG. 7), as described above. A graph 800 has an SpO₂ axis 801 and a time axis 802. The graph 800 shows a SpO₂ plot versus time 810 corresponding to the slow SpO₂ measurement 412 (FIG. 7). Shown along the time axis 802 is a constant SpO₂ value 812 corresponding to the SpO₂ threshold 701 (FIG. 7). Due to the short duration of irregular and intermittent drops in SpO₂, the slow SpO₂ measurement 810 does not fall below the SpO₂ threshold 812. Thus, the first alarm output 712 (FIG. 7) does not trigger an alarm in this example.

Also shown in FIG. 8, the graph 800 shows a SpO₂ plot versus time 820 corresponding to the fast SpO₂ measurement 422 (FIG. 7). Shown along the time axis 802 is a constant SpO₂ value 822 corresponding to the pattern threshold 734 (FIG. 7). A corresponding graph 805 has a logic level axis 806 and a time axis 807. The graph 805 shows a logic level plot versus time 830 corresponding to the extracted pattern output 722 (FIG. 7). The logic level plot 830 has a “1” level when the fast SpO₂ plot 820 is above the pattern threshold 822 and a “0” level when the fast SpO₂ plot 820 is below the pattern threshold 822. In this manner, the logic level plot 830 indicates the number and duration of times the fast SpO₂ plot 820 falls below a threshold value 822.

Further shown in FIG. 8, an alarm interval 870 along the time axis 802 corresponds to an alarm period indicated by the pattern comparator 740 (FIG. 7). This alarm interval 870 occurs after a reference pattern 732 (FIG. 7) is detected as matching an extracted pattern 722 (FIG. 7) and ends, correspondingly, when there is no longer a match. For example, assume that the reference pattern output 732 (FIG. 7) has the alarm criteria that at least three below threshold periods of minimum duration τ₁ must occur during a maximum period τ₂, where the value of τ₁ and τ₂ are illustrated along the time axis 807. The below threshold time periods 831-834 are each greater in duration than τ₂ and a first set of three, below-threshold time periods 831-833 occurs within a time period T₁=τ₂, as illustrated. Thus, the alarm interval beginning 872 is triggered by the second alarm output 742 (FIG. 7). A second set of three, below-threshold time periods 832-834 also occurs within a time period T₂=τ₂, as illustrated. Thus, the alarm interval 870 continues. There is no third set of three, below-threshold time periods. Thus, after the end of the time interval T₃=τ₂, the alarm interval end 874 is triggered. This example illustrates how the pattern recognition alarm indicator 320 (FIG. 7) can trigger an alarm on an event, such as a period of irregular heartbeats, that might be missed by a threshold-based alarm responsive to the slow SpO₂ measurement 412.

Although some alarm processor embodiments were described above in terms of pulse oximetry and oxygen saturation measurements, one of ordinary skill in the art will recognize that an alarm processor as disclosed herein is also applicable to the measurement and monitoring of other blood constituents, for example blood glucose and total hemoglobin to name a few, and other physiological parameters such as blood pressure, pulse rate, respiration rate, and EKG to name a few.

A parallel measurement alarm processor has been disclosed in detail in connection with various embodiments. These embodiments are disclosed by way of examples only and are not to limit the scope of the claims that follow. One of ordinary skill in the art will appreciate many variations and modifications. 

What is claimed is:
 1. An alarm processor which outputs at least one alarm signal when an indication of a blood oxygen saturation of a patient crosses at least one associated threshold value, the alarm processor comprising: a signal input responsive to a blood oxygen saturation of a patient; a plurality of parameter processors responsive to said signal input so as to provide a plurality of measurements indicative of said blood oxygen saturation, said measurements having differing characteristics; an alarm condition applicable to at least one of said measurements so as to define a limit for said measurement; and an alarm indicator operating on said measurements and said alarm condition so as to provide an alarm output that changes state to indicate that said measurement may have exceeded said limit.
 2. An alarm processor comprising: a signal input responsive to a physiological parameter; a plurality of parameter processors responsive to said signal input so as to provide a plurality of measurements of said parameter, said measurements having differing characteristics; an alarm condition applicable to at least one of said measurements so as to define a limit for said parameter; and an alarm indicator operating on said measurements and said alarm condition so as to provide an alarm output that changes state to indicate that said parameter may have exceeded said limit, wherein said parameter processors include: a first processor configured to derive a smoothed measurement of said physiological parameter from said signal input; and a second processor configured to derive a predictive measurement of said physiological parameter from said signal input.
 3. The alarm processor according to claim 2 wherein said alarm condition is a threshold and said alarm indicator comprises: a threshold detector that inputs said smoothed measurement and said threshold and provides a threshold detector output responsive to said smoothed measurement crossing said threshold; a slope detector that inputs said predictive measurement and provides a slope detector output responsive to a slope of said predictive measurement; and an alarm detector that inputs said threshold detector output and said slope detector output and generates said alarm output, said alarm output responsive to said slope being negative at the same time said smoothed measurement is less than said threshold.
 4. An alarm processor comprising: a signal input responsive to a physiological parameter; a plurality of parameter processors responsive to said signal input so as to provide a plurality of measurements of said parameter, said measurements having differing characteristics; an alarm condition applicable to at least one of said measurements so as to define a limit for said parameter; an alarm indicator operating on said measurements and said alarm condition so as to provide an alarm output that changes state to indicate that said parameter may have exceeded said limit; and a second alarm condition applicable to at least one of said measurements so as to define a corresponding second limit for said parameter, wherein said alarm indicator also operates on said second alarm condition so as to provide a second alarm output that changes state to indicate that said parameter may have exceeded said second limit.
 5. The alarm processor according to claim 4 wherein said parameter processors include: a first processor configured to derive a smoothed measurement of said physiological parameter from said signal input; and a second processor configured to derive a predictive measurement of said physiological parameter from said signal input.
 6. The alarm processor according to claim 5 wherein said first alarm condition and said second alarm condition comprise a measurement threshold and a reference pattern, said alarm indicator comprising: a threshold detector that inputs said smoothed measurement and said measurement threshold and provides said alarm output, said alarm output responsive to said smoothed measurement crossing said threshold; a pattern extractor that inputs said predictive measurement and a pattern threshold and provides an extracted pattern responsive to a plurality of predictive measurement features; a reference pattern that specifies a plurality of pattern features; and a pattern comparator that inputs said extracted pattern and said reference pattern and generates said second alarm output, said second alarm output being responsive to the matching of said pattern features with said measurement features.
 7. The alarm processor according to claim 6 further comprising: a pattern memory having a memory output in communications with said pattern comparator; a plurality of patterns stored within said pattern memory; and a memory input to said pattern memory; said pattern memory responsive to said pattern selection on said memory input so as to retrieve a particular one of said patterns as said reference pattern to said memory output.
 8. The alarm processor according to claim 7 wherein one of said pattern features is indicative of the time duration that said predictive measurement is below said pattern threshold.
 9. The alarm processor according to claim 7 wherein one of said pattern features is indicative of the number of times said predictive measurement is below said pattern threshold within a specific time period.
 10. A alarm method comprising the steps of: inputting a sensor signal responsive to a physiological parameter; processing said sensor signal to provide an smoothed measurement of said parameter and a predictive measurement of said parameter; and triggering an alarm based on both said smoothed measurement and said predictive measurement.
 11. The alarm method according to claim 10 wherein said trigger step comprising the substeps of: specifying an alarm condition; and applying said alarm condition to at least one of said smoothed measurement and said predictive measurement to generate an alarm output.
 12. The alarm method according to claim 11 wherein said alarm condition is a threshold and said applying substep comprises the substeps of: changing a first output state in response to the value of said smoothed measurement relative to said threshold; changing a second output state in response to the slope of said predictive measurement; and combining said first output state and said second output state to generate said alarm output.
 13. The alarm method according to claim 11 wherein said parameter is oxygen saturation and said applying substep comprises the substeps of: not asserting said alarm output when the value of said smoothed measurement is above said threshold or when the slope of said predictive measurement is positive, so as to suppress alarms when said parameter indicates oxygen saturation is in a normal range or is recovering toward a normal range; and asserting said alarm output when the value of said smoothed measurement is below said threshold and when the slope of said predictive measurement is non-positive, so as to suppress alarms when said parameter indicates oxygen saturation is below normal and is not recovering toward a normal range.
 14. The alarm method according to claim 11 wherein said at least one alarm condition is a measurement threshold and a reference pattern and said applying substep comprises the substeps of: changing a first output state in response to the value of said smoothed measurement relative to said threshold; extracting a feature pattern from said predictive measurement using a pattern threshold; changing a second output state in response to a comparison of said reference pattern with said feature pattern; generating said alarm output in response to said first output state; and generating a second alarm output in response to said second output state.
 15. The alarm method according to claim 14 comprising the further substeps of: storing a plurality of patterns and an associated plurality of pattern thresholds; selecting one of said patterns to output as said reference pattern; and generating one of said associated pattern thresholds.
 16. The alarm method according to claim 11 wherein said parameter is oxygen saturation and said applying substep comprises the substeps of: asserting a first one of said at least one alarm output when the value of said smoothed measurement is below a first threshold, so as to indicate when oxygen saturation is below a normal range; and asserting a second one of said at least one alarm output when said predictive measurement crosses a second threshold a specified number of times within a specified time period so as to indicate when oxygen saturation is unstable.
 17. A pulse oximeter capable of generating at least one alarm when at least one signal indicative of blood oxygen saturation is outside acceptable ranges, the pulse oximeter comprising: a processor means for deriving a plurality of differing measurements indicative of a blood oxygen saturation of blood pulsing within body tissue; a condition means for specifying a limit on said measurement, said condition means applied to at least one of said measurements; and an indicator means for generating an alarm in response to said condition means.
 18. An alarm processor comprising: a processor means for deriving a plurality of measurements of a physiological parameter; a condition means for specifying a limit on said parameter, said condition means applied to at least one of said measurements; and an indicator means for generating an alarm in response to said condition means and said measurement means, wherein said processor means comprises: an integrator means for providing a smoothed measurement of said parameter; and a predictor means for providing a predictive measurement of said parameter.
 19. The alarm processor according to claim 18 wherein said condition means comprises: a threshold applied to a smoothed measurement to determine a normal range for said parameter; and a pattern applied to a predictive measurement to determine an abnormal feature of said parameter.
 20. The alarm processor according to claim 18 wherein said indicator means comprises: a threshold means to indicate the state of said smoothed measurement; a slope means to indicate a trend of said predictive measurement; and a alarm means for suppressing the output of said threshold means with the output of said slope means.
 21. A patient monitoring device capable of reducing a number of false alarms in a pulse oximetry system, wherein the pulse oximetry system comprises the patient monitoring device and a noninvasive optical probe including at least one emitter and a light-sensitive detector capable of outputting at least one signal indicative of oxygen saturation in pulsing blood based on light from the at least one emitter that has been attenuated by body tissue, the patient monitoring device comprising: an input capable of receiving a signal responsive to a blood oxygen level in pulsing blood; processing circuitry capable of generating from the signal a plurality of measurements indicative of the blood oxygen level, wherein the plurality of measurements include at least one measurement that is comparatively slow and at least one measurement that is comparatively fast; an alarm indicator capable of generating at least one alarm signal when the comparatively slow measurement is below a threshold value and the fast measurement meets defined alarm criteria.
 22. The patient monitoring device of claim 21, wherein the alarm criteria comprise trend analysis criteria.
 23. The patient monitoring device of claim 22, wherein the trend analysis criteria comprises analysis of a direction of change in the fast measurement.
 24. The patient monitoring device of claim 21, wherein the alarm criteria comprise pattern recognition criteria.
 25. The patient monitoring device of claim 24, wherein the pattern recognition criteria comprises analysis of a patterns in the fast measurement.
 26. The patient monitoring device of claim 21, wherein the comparatively slow measurement comprises a smoothed measurement.
 27. The patient monitoring device of claim 21, wherein the comparatively fast measurement comprises a predictive measurement. 